Abstract
Olanzapine is a 2nd generation or atypical antipsychotic medicine belongs to thienobenzodiazepine group that blocks the serontonin (5-Hydroxytryptamine [5-HT]) 5-HT2A and the Dopamine (D2) receptors in particular, and also blocks Muscarinic (M1), Histamine (H1), 5-HT2C, 5-HT3 to 5-HT6, adrenergic (αl), and D4 receptors. The olanzapine has greater affinity for blocking 5-HT2A receptors in comparison with D2 receptors in comparison to other antipsychotics except Clozapine and Quetiapine. Olanzapine is most commonly prescribed for treatment of overall positive and negative symptoms of schizophrenia, for acute, management of mania, and as Olanzapine- fluoxetine combination in bipolar depression. It is shown to possess antidepressant activity without destabilizing the mood. It is usually well tolerated But most common side effects of the drug is sedation. The patient stated that he was suffering from sleep problem and was facing problem in procuring Benzodiazepines. On suggestion of his friend, he started taking Olanzapine as sleeping pill. Soon he discovered that it would make him feel cloudiness of mind “get stoned”, to which he liked most. It was a prime motivation for abusing olanzapine.
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