Olanzapin ve Mirtazapin'in Birlikte Kullanımıyla İlişkili Periferik Ödem: Olgu Sunumu

Abstract

Peripheral edema is most commonly associated with multiple medical etiologies (hepatic cirrhosis, lymphedema, congestive heart failure, hypoproteinemia and renal dissease) and drugs (NSAID, antyhypertensives, steroids, and immunosupressive agents). Olanzapine and mirtazapine are rarely related with peripheral edema. Olanzapine blocks a1, M1, H1, and 5HT2 receptors peripherally result in vasodilation and decreased vascular resistance, which predisposes to peripheral edema. However, peripheral edema caused by the use of mirtazapine, which mechanism is unknown. Here, we report one case of peripheral edema secondary to olanzapine-mirtazapine combination in a schizophrenic patient. To the best of our knowledge, this is the first report of peripheral edema associated with olanzapine-mirtazapine combination.