Abstract
After verification of the relevant trial data with real-world registries, it is now a widely accepted fact that Non-Vitamin K oral anticoagulants (NOACs) offer at least equal efficacy about stroke risk reduction with less bleeding events in comparison to Vitamin K antagonists. Spontaneous serous bleeding (pericardial or pleural) is a quite rare complication of NOAC treatment which had just been previously reported in a few cases with dabigatran, rivaroxaban, and apixaban. Here we present a 72-year-old patient receiving apixaban, who was diagnosed to have a massive right pleural hemorrhagic effusion during conventional heart failure treatment. Effusion was drained immediately. Reversal of anticoagulation or blood transfusion was not required.
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