Abstract
Oxytocin is traditionally associated with parturition and lactation. The similarity in oxytocin plasma levels in males and females implies a wider physiological role for the hormone. Oxytocin would now appear to be involved not only in milk ejection, but also in the production of milk. The hormone has further been shown to play a paracrine role in menstruation and to be of importance for normal fertilisation. Several endocrine modulatory as well as neurotransmitter effects have also been reported for oxytocin. The discovery of the role of oxytocin in central nervous system processes such as pain, anxiety, memory and learning has stimuluted a search for possible therapeutic applications of oxytocin in cases such as chronic pain and Alzheimer’s disease. A short review is presented of some of the biochemical and physiological aspects underlying the functions and possible therapeutic applications of oxytocin.
Highlights
O x y to c in is tra d itio n a lly asso cia ted w ith p a rtu ritio n a n d la cta tio n
Terselfdertyd word die hipotalam us gestimuleer vir verhoogde produksie en aksontransport . ' '^^ D ie verhoogde oksito sien sek resie in respons op tepelstimulering is in nieswanger vroue van kleiner om vang as in swanger vroue, en varieer afhangend v a n die fase v a n die m e n s tr u e le siklus.^’® D ie F e rg u s o n re
Die vergelykbare oksitosien-plasmavlakke in die m an en die vrou skep die indruk dat die perifere effekte van oksitosien wyer mag strek as die tradisioneel aanvaarde funksies van melksekresie en uteruskontraksies tydens kraam en koitus
Summary
Follikulére vog Oorsprong (normaal, nieswanger, basale waardes) follikulêre fase follikulêre fase follikulêre fase middesiklus luteale fase luteale fase luteale fase swangerskap, 3-9 weke swangerskap, weke swangerskap, weke prelaktasie 2 minute postlaktasie 10 minute postlaktasie borsstimulasie orale kontrasepsie
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