Ointment of Ximenes americana promotes acceleration of wound healing in rats1.

José De Castro Souza Neto Júnior,Marcela Gabriela Feitosa Vieira,Ricardo Santos Simões,Joaquim Evêncio-Neto,Adriana Aparecida Ferraz,Lígia Reis De Moura Estevão

doi:10.1590/s0102-865020190030000007

Abstract

Purpose To evaluate the healing potential of the Ximenia americana hydroalcoholic extract in 10% cream in excisional wound models in rats. Methods Sixty male adults Wistar rats were submitted to skin and subcutaneous tissue surgery in the right and left thoracic regions, divided into three experimental groups: Standard submitted to treatment with only the base vehicle, Treated wounds treated with hydroalcoholic extract of X. americana applied on 10%, Lanette base and Control, untreated wounds. The treatment was performed daily and the wounds evaluated microscopically by the quantification of fibroblasts, collagen fibers and blood vessels. Results The histomorphometric analysis showed a significant increase in the number of fibroblasts, collagen fibers and blood vessels in the treated group. Conclusion The topical action of the cream based on Ximenia americana shows angiogenic effects and improves the replacement of collagen, suggesting its use for the development of herbal remedy in the treatment of cutaneous wound healing.

Highlights

Since ancient times man uses products derived from plants with curative power, and nowadays most of the medicines used had the same origin and principle 1
Due to the enormous biodiversity of native species present in northeastern Brazil there is one that we tried to evaluate because it is normally used by the population[1,2]. Besides this it could be used as a potential source for the development of new natural products, among which the Ximenia americana (X. americana), popularly known as yellow plum, wild plum or sea lime[2]
Sixty adult male rats (Rattus norvegicus albinus), ±300g, from the Department of Morphology and Physiology of the UFPE were used in this experiment and the care and procedures used such as: anesthesia,trichotom y,preparation of the Ximenia americana branch extract,preparation of cutaneous lesions, as well as treatment of groups such as ointment application were already described in Castro Souza et al.[21]

Summary

Introduction

Since ancient times man uses products derived from plants with curative power, and nowadays most of the medicines used had the same origin and principle 1. Due to the enormous biodiversity of native species present in northeastern Brazil there is one that we tried to evaluate because it is normally used by the population[1,2] Besides this it could be used as a potential source for the development of new natural products, among which the Ximenia americana (X. americana), popularly known as yellow plum, wild plum or sea lime[2]. The use of this species has demonstrated strong curative power due to the presence of considerable bioactive compounds related to antioxidant activity, tannins and flavonoids[1,3]. It is commonly used in insect bites and has antipyretic activity[4,5,6,7]

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Conclusion