Abstract
Using saliva as a diagnostic fluid has increased exponentially in the past decade because of recent technologic developments. To identify protein biomarkers in saliva that could be associated with the pathogenesis of oral diseases is an interesting topic of research. However, at present, the accurate and reliable detection of protein biomarkers in saliva has yet to be achieved, owing to lack of standardized laboratory protocols in the analysis of highly complex and viscous saliva specimens. We therefore aim to create a common consensus on the detection of salivary biomarkers regarding saliva handling, the application into methodologic assays, and the presentation of the results. For this purpose, we evaluated the improvement of detection levels for interleukin 8 (IL-8) and epidermal growth factor (EGF) by the pretreatment of saliva samples with an anionic detergent, sodium dodecyl sulfate (SDS).
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