OGC P46 Positive Circumferential margins are associated with poorer survival following surgery in gastro-oesophageal junctional cancers

Abstract

Abstract Background Adenocarcinoma of the gastro-oesophageal junction (GOJ) remains a significant clinical problem that is increasing in incidence and is associated with a poor prognosis. The aim of this study is to determine the effects of the resection margins on survival and recurrence. Methods A retrospective study was conducted at our hospital from March 2001 till December 2022. All the patients that had oesophagectomy for gastro-oesophageal junctional (GOJ) adenocarcinoma were included in this study. Demography, staging, margins, type of neo-adjuvant chemotherapy and survival data were collected. Results Over the study, 174 patients had Gastro-oesophageal junctional adenocarcinoma. 42 of the patients had circumferential margins positive and 132 had negative circumferential margins. The median for survival is 18 months in circumferential margins positive and 31 months for the circumferential negative patients with a P value of <0.001 There were no patients with longitudinal margins positive enough to calculate any statical analysis The median of recurrence is 13.4 months for the circumferential margins positive and 26.8 months for the circumferential margins negative patients with a P value on 0.003 Conclusions The presence of any circumferential margin tumour will significantly affect the survival rate and recurrence rate.