Abstract
IntroductionProlonged acid reflux monitoring using wireless pH monitoring (WPM) may be performed following pH impedance in suspected false negative cases. The increased yield of Gastro-esophageal reflux disease (GERD)-positive diagnoses with...
Highlights
The SPIT study aims to investigate the methylation changes in saliva that result from oesophagael cancer with the ultimate aim of developing a diagnostic biomarker
We aimed to evaluate the ability of Cytosponge-TFF3 to detect Gastric IM (GIM)/GA in the stomach
The presence of GA/GIM was compared in TFF3 positive (TFF3+) and TFF3 negative (TFF3-) patients using Fisher’s exact test
Summary
The SPIT study aims to investigate the methylation changes in saliva that result from oesophagael cancer with the ultimate aim of developing a diagnostic biomarker. Methods The increased GERD-positive diagnostic yield with WPM was determined in 181 consecutive patients who had undergone negative pH impedance with HRM. Results Of the 181 included, using average day analysis 61 studies were positive for GERD (Male : Female 26: 35, average age of 47 (15) years and 120 negative for GERD (Male: Female 52: 68 average age of 48 (15) years. This corresponds to 33.70% of the patients initially diagnosed as not having GERD, being given a diagnosis of GERD at WPM.
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