Abstract
We compared the central retinal vascular trunk (CRVT) position, as a surrogate of lamina cribrosa (LC) offset, with the anterior scleral opening (ASCO) offset from the Bruch’s membrane opening (BMO). Based on the BMO-centered radial scans, the BMO and ASCO margins were demarcated, and each center was determined as the center of the best-fitted ellipse for each margin. The ASCO/BMO offset was defined as the offset between each center. Angular deviations and the extent of ASCO and CRVT offsets from the BMO center were compared directly. Incomplete demarcation of ASCO was found in 20%, which was associated with a larger BMO area and a larger ASCO offset from the BMO. The angular deviation of ASCO offset was associated with that of CRVT offset and that of the longest externally oblique border. The ASCO offset was smaller than the CRVT offset, and, unlike the CRVT offset, it was rarely deviated to the inferior side. The complete ASCO margin might not be demarcatable when determined on BMO-centered radial scans in the presence of an offset. Also, the ASCO, which reflects only the superficial scleral layer, might not reflect the LC position, because the LC might be shifted further from the ASCO.
Highlights
We compared the central retinal vascular trunk (CRVT) position, as a surrogate of lamina cribrosa (LC) offset, with the anterior scleral opening (ASCO) offset from the Bruch’s membrane opening (BMO)
6 subjects were excluded due to incomplete ASCO demarcation for more than 90° continuously, 2 subjects due to incomplete BMO demarcation, 1 due to poor spectral-domain (SD) optical coherence tomography (OCT) image quality, and 1 due to bifurcation of the CRVT, which resulted in a final sample of 106 eyes of 106 subjects (53 open-angle glaucoma eyes and 53 eyes without glaucoma)
We discovered that the ASCO center was deviated from the BMO center and that this offset was closely associated with the CRVT position in both directionality and extent
Summary
We compared the central retinal vascular trunk (CRVT) position, as a surrogate of lamina cribrosa (LC) offset, with the anterior scleral opening (ASCO) offset from the Bruch’s membrane opening (BMO). Shift and consequent offset of LC is clinically important, since it can explain the association of all these changes with the preferential site of glaucomatous damage[18,19] In those studies, the LC offset was estimated with reference to that of the central retinal vascular trunk (CRVT)[14,15,16,17], because the CRVT is embedded in the dense connective tissue of the LC20 and is located in the center of ONH in most of newborns[21,22]. The purpose of this study, was to compare ASCO center offset and CRVT offset from the BMO center, as representative of ASCO/BMO and LC/BMO offsets, respectively
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