Office Blood Pressure Monitoring in Children with Obesity and Obstructive Sleep Apnea

Abstract

To investigate the relative contributions of obesity and obstructive sleep apnea (OSA) to unfavorable blood pressure in children. Children aged 3-18years with OSA-related symptoms were recruited. All children underwent office blood pressure (BP) monitoring and full-night polysomnography. Obesity was defined as a body mass index ≥95th percentile. OSA severity was divided into primary snoring (apnea-hypopnea index [AHI] <1), mild OSA (5> AHI ≥1), and moderate to severe OSA (AHI ≥5). Age- and sex-adjusted logistic regression analysis was performed to determine the associations among OSA, obesity, and elevated BP. This cross-sectional study enrolled 1689 children (66% boys), with a mean age of 7.9years. Compared with children with primary snoring, children with moderate to severe OSA had significantly higher systolic BP (108.1mmHg vs 105.6mmHg), diastolic BP (75.0mmHg vs 70.4mmHg), systolic BP percentile (75.0 vs 70.4), and diastolic BP percentile (74.0 vs 69.2). The rate of unfavorable BP (ie, elevated BP or hypertension level BP) also was significantly higher in children with more severe OSA. Children with obesity had higher BP and BP percentile. Logistic regression analysis revealed that children with obesity and moderate to severe OSA have a 3-fold greater risk of unfavorable BP compared with children without obesity and primary snoring. We identified a 3-fold greater risk of unfavorable BP in children with obesity and moderate to severe OSA.