Abstract

The proposition that drugs should not be used ‘off-label’ seems, at first glance, to be one that fits with the zeitgeist. We are all encouraged to practice evidence-based medicine. Our traditional clinical freedom is all too often shown to be an excuse for anecdote to trump scientific standards of proof, and guidelines, managed care and clinical pathways are being increasingly imposed, often for good reason and to good effect, to rein in our more maverick tendencies. Why then should we not restrict ourselves to using drugs for the indications and in the doses, routes of administration and formulations for which they have been licensed and, therefore one must assume, rigorously tested?

Full Text
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