Abstract
Plasma membranes are believed to be highly heterogeneous, and to contain coexisting liquid-ordered domains (known as rafts), which are enriched in cholesterol and sphingomyelin, and liquid-disordered domains. Similar heterogeneities exist in synthetic membrane systems. Previous studies of asymmetric lipid bilayers have demonstrated that the presence of domains in one (outer) leaflet of the bilayer can induce domain formation in the other (inner) leaflet, a phenomenon known as interleaflet coupling (1–3).
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