Abstract
Expansions in C9ORF72, which cause frontotemporal dementia and amyotrophic lateral sclerosis, result in formation of aberrant peptide and RNA species and decreased expression of the normal gene. In this issue of Neuron, Lall etal. (2021) report the consequences of microglial C9ORF72 deficiency in mouse models of aging and Alzheimer's disease.
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