Abstract
The magnitude of immunological differences between species has been used to estimate the time of divergence of lineages, especially among primates. Calibration of “clocks” based on immunological differences has relied heavily on data from Pakistan suggest that the lineages leading to Mus and Rattus diverged between 14 and 8 million years ago rather than 30 or more million years ago as suggested by techniques invoking constant rates of molecular evolution. Molecular analyses of pairs of mammal species which appear well documented paleontologically should be undertaken in order to expand our understanding of the tempo and mode of molecular evolution.
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