Abstract
ABSTRACT Oestriol-16-14C was injected into the umbilical vein of a newborn anencephalic monster and the circulating and excreted radioactive material was analysed. Ten to twelve minutes following injection more than 98 per cent of the circulating radioactive material was in a conjugated form. More than 75 per cent of this conjugated material was identified as oestriol-3-sulphate and more than 20 per cent as oestriol-3-sulphate,16(17?)-glucosiduronate. No oestriol-16(17?)-glucosiduronate could be detected in the blood. Less than 1.0 per cent of the radioactive material was excreted in the urine as unconjugated oestriol. Approximately 50 per cent was present as oestriol-16(17?)-glucosiduronate, more than 16 per cent as oestriol-3-sulphate and more than 25 per cent as oestriol-3-sulphate,16(17?)-glucosiduronate. At least 98 per cent of the oestrogen moiety of the various radioactive conjugates was identified as oestriol.
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