Abstract
The decrement in quality of life to a patient with unexplained oesophageal symptoms cannot be overemphasised. A life lived with dysphagia or chest pain, without a specific diagnosis, can affect a patient on a daily basis (or even every meal). Evaluation usually begins with routine upper endoscopy. The addition of advanced imaging, a biopsy, or specialised brushing all too often fails to result in a conclusive diagnosis. Promising technologies to assess inflammation (ie, tissue impedance), 1 Ates F Yuksel ES Higginbotham T Mucosal impedance discriminates GERD from non-GERD conditions. Gastroenterology. 2015; 148: 334-343 Summary Full Text Full Text PDF PubMed Scopus (111) Google Scholar lower oesophageal sphincter distensibility, and motility (ie, endolumenal functional imaging probe) 2 Carlson DA Kahrilas PJ Lin Z et al. Evaluaiton of esophageal motility utilizing the functional lumenal imaging probe. Am J Gastroenterol. 2016; 111: 1726-1735 Crossref PubMed Scopus (137) Google Scholar are not ready for widespread use. The barium swallow is a lost art, providing variable information on motility, and is often performed without a solid bolus, limiting its usefulness. Diagnostic yield of high-resolution manometry with a solid test meal for clinically relevant, symptomatic oesophageal motility disorders: serial diagnostic studyThe diagnostic sensitivity of HRM for major motility disorders is increased with use of the STM compared with SWS, especially in patients with dysphagia. Observations made during STM can establish motility disorders as the cause of oesophageal symptoms. Full-Text PDF Pharyngeal swallowing and oesophageal motility during a solid meal test: a prospective study in healthy volunteers and patients with major motility disordersOur results show normative values for pharyngeal swallowing and oesophageal motility in healthy volunteers. Detailed analysis of HRM data acquired during an STM shows that the rate-limiting factor for intake of solids in health is the frequency of pharyngeal swallowing and not oesophageal contractility. The reverse is true in patients with oesophageal motility disorders, in whom the frequency of effective oesophageal contractions determines eating speed. Full-Text PDF
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