ODP379 Brain MRIs may be value in children with isolated growth hormone deficiency whose peak GH level below 5 ng/mL in two growth hormone provocation test

Abstract

Abstract Brain MRIs are considered essential in the evaluation of children diagnosed with growth hormonedeficiency (GHD), but there is uncertainty about the appropriate cut-off for diagnosis of GHD and little data about the yield of significant abnormal findings in patients with peak growth hormone (GH) of 7–10 ng/mL. We aimed to assess the frequency of pathogenic MRIs and associated risk factors in relation to peak GH concentrations. In this retrospective multicenter study, charts of patients diagnosed with GHD who subsequently had a brain MRI were reviewed. MRIs findings were categorized as normal, incidental, of uncertain significance, or pathogenic pituitary hypoplasia, small stalk and/or ectopic posterior pituitary and tumors. Of the 379 patients with GHD, 60.4% had normal MRIs. 22.4% had incidental findings, 3.2% had pathogenic findings including ectopic pituitary gland, pituitary hypoplasia, and pituitary stalk interruption syndrome. Patient with peak GH level <5 ng/mL had a significantly higher prevalence of pathogenic findings. Presentation: No date and time listed