ODP376 Accuracy of Doppler Assessment of the Uterine Arteries for the Diagnosis of Pubertal Onset in Girls: A Scoping Review

Abstract

Abstract Introduction The uterine artery pulsatility index (PI) assessed by Doppler ultrasonography (US) reflects the blood flow impedance in the vessel distal to the sampling point and tends to decrease with the onset of puberty, being suggested as a parameter to define pubertal development. Objective To evaluate the accuracy of the uterine artery PI for the diagnosis of puberty in girls. Methods A PRISMA-ScR-compliant scoping review was performed in the MEDLINE and Embase databases with "puberty" and "Doppler ultrasonography" as search terms. Studies that included girls aged 0-18 years who underwent pelvic US with Doppler of the uterine arteries and calculation of the PI were considered eligible. Results Ten studies comprising 1385 girls aged 1.2-18 years were included. The selected studies were published between 1996 and 2021 and included participants from five countries (Italy, Brazil, Iran, Belgium and Denmark). Six studies included girls who were referred for evaluation of pubertal disorders, mainly thelarche or early-onset pubarche, while four studies selected only healthy girls. Nine studies found a significant difference in Doppler and PI according to pubertal stage, with PI cutoff points ranging from 2.5 to 4.6 for the diagnosis of onset of puberty, with a sensitivity of 77-94%, specificity of 85-100% and accuracy of 79-98%. Conclusion Doppler assessment of the uterine arteries with PI calculation is a useful noninvasive tool in the diagnosis of onset of secondary sexual characteristics in girls. Presentation: No date and time listed