ODP237 Relation Between Long Term Glycemic Variability (LTGV) and HbA1c Time-In-Range in Diabetic Patients.

Abstract

Abstract Background LTGV has become, aside with mean Hba1c level, a new measure of glycemic control. Despite the burden of information about its association to long term diabetic complications, in real-life is uncertain its relation to glycemic control. Objective to describe in real-life conditions the relation between long term LTGV and glycemic control. Methods from our clinical laboratory data base we selected those patients who attended for HPLC´s determination of HbA1c for at least two times in 2 consecutive years. We discard those results from patients with anemia or kidney failure. To evaluate LTGV in all patients that fulfill the requirements HbA1c variation coefficient (VC) were calculated ((HbA1c SD/mean HbA1c)X100). Time in control range were assessed as the percent of results below 7% during follow up. Patients were categorized in quartiles according to VC and percent of determinations of Hba1c <7%. (HbA1c< 7). We compared the frequency low vs high VC (quartile 1 vs 4) in patients divided by HbA1c< 7 quartiles and VC levels between hba1c<7 quartiles. Results we studied 193 patients (52.8% men, 61.23 (12.81) years, 925(171) days of follow up).: Percent of patients with low vs high VC quartiles (1 vs 4 respectively) divided by HbA1c<7 quartiles were: quartile 1: 57% vs 0. 0%, quartile 2: 19.6% vs 52.9%, quartile 3: 10.2% vs 57.1% and quartile 4: 18.3% vs 20%. (p<0. 05 quartile 1 vs 2,3,4 and quartile 3 vs 4). VC level were (quartiles 1 to 4 respectively, mean (SD)): 5.42(3), 22(15), 21.34(11),13(7). (p<0. 05 quartile 1 vs 2,3,4, quartile 2 vs 4, quartile 3 vs 4). Conclusions High glycemic variability is rare observed in patients with excellent glycemic control but seems very frequent in those with less than perfect controlled patients (quartiles HbA1c<7, 2 and 3) even in comparison to patients never controlled (quartile 4). VC levels are also higher in those patients in intermediate Hba1c <7 quartiles. It is very interesting that those patients never controlled(HbA1c<7 quartile 4) has no either the higher level of VC or frequency of high VC. Presentation: No date and time listed