ODP206 High Burden of Chronic Kidney Disease in Young Adults with Type 1 Diabetes

Abstract

Abstract Background Type 1 diabetes (T1D) increases the risk of chronic kidney disease (CKD). We sought to assess the burden of CKD and albuminuria, and risk factors contributing to CKD development. Methods This retrospective cohort study (1996-2020) involved Canadian adults diagnosed with T1D before 30 years of age, followed in a sub-speciality clinic in British Columbia. CKD was defined as an estimated GFR <60 ml/min/1.73 m 2 and persistent albuminuria was defined as a urine albumin-to-creatinine ratio (ACR) ≥2 mg/mmol (≥2 measurements over 6 months). Logistic regression was used to describe the relationship between CKD and diabetes-related risk factors. Results Of the 268 adults followed in the clinic, 63.4% were male, and the median age at diagnosis of T1D was 13.7 years (IQR 11.9 years). Over a median duration of T1D of 27.1 years (IQR 21.2 years), 8.2% of the adults developed CKD and 32.5% developed albuminuria (19.8% ACR 2-20 mg/mmol, 12.7%≥20 mg/mmol). Five adults went on to develop end-stage renal disease within the follow-up period. A longer duration of T1D (≥30 years) was associated with 4-fold increase in the odds of developing CKD (odds ratio 4. 09, 95% CI 1.37-15.10). History of medical and psychiatric comorbidities, A1C≥7%, systolic blood pressure ≥130 mmHg, and ACR ≥2 mg/mmol were also associated with greater odds of developing CKD. Conclusion In this contemporary Canadian cohort of young adults with T1D, CKD and albuminuria are common. Contributing risk factors include comorbid medical and psychiatric conditions, suboptimal glycemic control, systolic hypertension, and albuminuria. Presentation: No date and time listed