ODP151 Hypothyroidism and Cardiac Remodeling in Ischemic Strokes

Abstract

Abstract Hypothyroidism has been shown to increase the risk of developing cardiovascular disease (CVD), yet the mechanism is not well described. Previous studies correlated hyperlipidemia, diastolic hypertension, and smoking with impaired thyroid function, which serve as independent risk factors for CVD. Our study seeks to understand the prevalence of hypothyroidism in ischemic strokes. We hypothesize that hypothyroidism may exacerbate the severity of co-morbidities accelerating cardiac remodeling and risk for ischemic strokes. Our multi-center retrospective study constructed a database of 646 patients who were admitted over a three year period for a primary diagnosis of ischemic stroke. Detailed chart review excluded patients with known risk factors for ischemic strokes including: atrial-fibrillation, atrial-flutter, prior stroke, carotid artery stenosis, thromboembolic disease, and an active cancer diagnosis. Cardiac remodeling was identified by the hallmark finding of left atrial enlargement (LAE) on transthoracic echocardiogram (TTE) with severity determined as a composite measurement of either left atrial diameter (LAD) or left atrial volume index (LAVI). Inclusion criteria were met by 482 patients (75%), where 349 (54%) were female, 435 (67%) were Caucasian, 390 (60%) had hypertension, 360 (56%) had hyperlipidemia, 291 (45%) were previous or current tobacco users, and 199 (31%) had diabetes. Our preliminary analysis found that 83 (13%) of patients had a diagnosis of hypothyroidism. Of note, TTE reports available for 225 (35%) of patients, wherein 74 (33%) of patients met at least one criteria for LAE. Our initial findings support further subgroup analysis to characterize the significance of hypothyroidism as a comorbidity in the development of ischemic strokes. Further research may identify the individual contribution of hypothyroidism to the severity of cardiac remodeling, as well as the impact of treatment for hypothyroidism in stroke risk reduction. Our preliminary analysis found 74 (48%) of patients met at least one criteria for LAE. Presentation: No date and time listed