ODP089 Familial correlation and heritability of muscle strength in Korean adults (KNHANES 2014-2019)

Abstract

Abstract Objective The onset and progression of sarcopenia are highly variable between individuals due to genetic and environmental factors. However, studies that have measured muscle strength directly in large numbers of matched parent-adult offspring pairs are limited. In this study, we investigated familial correlation and heritability of handgrip strength (HGS) in Korean adults. Methods This was a family-based cohort study from the Korea National Health and Nutrition Examination Survey (2014-2019) including 5,004 Koreans aged ≥19 years from 1,527 families. HGS was measured using a digital grip strength dynamometer. Familial correlations for HGS were calculated in different types of relative pairs. Variance component methods were used to obtain heritability estimates. Results Mean HGS of parents were 39.3 ± 7.5 kg in fathers and 24.4 ± 5. 0 kg in mothers and those of offspring were 41.8 ± 8. 0 kg in sons and 24. 0 ± 4.8 kg in daughters. Correlation coefficient estimates between parent-offspring pairs, sibling pairs, and spouse pairs for HGS were significant as 0. 07, 0.10, and 0.23 (p <0. 001, p = 0. 041, and p <0. 001), respectively. The total variance of the phenotype under study was explained by additive genetic (15.4%), common shared environmental (11. 0%), and unique environmental (73.6%) influences. The risk of low HGS conferred by parents’ low HGS were found to be significant for individuals whose parents had low HGS (OR 3.10, 95%CI 1.14-8.45). Conclusion Muscle strength showed a familial correlation in Korean adults. A significant heritable tendency of muscle strength from parents to their adult offspring and common shared environmental influence can explain this correlation. Presentation: No date and time listed