ODONTOGENIC-RELATED MICRO INFLAMMATION IN PATIENTS WITH HYPERTENSION AND CHRONIC KIDNEY DISEASE: PP.15.78

Abstract

Background: Micro-inflammation in patients with chronic kidney disease seems to be an important factor in the pathogenesis of accelerated atherosclerosis. The source of micro-inflammation usually left undetectable. Dental and peridental diseases may have important influence on micro-inflammation status in patients with chronic kidney disease (CKD). Aim of the study was to analyze concentration of selected inflammatory markers in CKD patients with potential dental and peridental diseases. Patients and Methods: Sixty eighty adult patients with arterial hypertension and stadium 1–4 of CKD were enrolled into the study. Based on clinical and X-ray examination patients were divided on 5 groups: group I (n = 12) - patients with teeth after endodontic treatment without periapical lesions, group II (n = 8) - patients with teeth with gangraena pulpae without periapical lesions, group III (n = 22) - patients with teeth with periapical lesions, group IV (n = 7) - patients with periodontal disease, and control group - with health teeth (n = 19). The evaluation was based on the Gingival Index (GI, scores 2 and 3) proposed by Löe and Silness, and the Russell's Periodontal Index (scores 6 and 8). Patients with multiple dental pathology and evidence of other then odontogenic infection were excluded from the study. In all patients serum hsCRP and hsIL-6 concentrations measured. Results: Similar concentration of serum CRP concentrations were observed in all studied groups [I-4.0(0.5–7.5)mg/L II-5.1(2.8–7.4)mg/L; III-3.7(1.8–5.5)mg/L; IV-3.2(1.6–4.8)mg/L; C-4.5(1.9–7.0)mg/L]. Significantly higher serum IL-6 concentrations were observed only in group II then in the control group [3.15(0.39–6.69) pg/mL vs. 0.91(0.63–1.18)pg/mL; p = 0.02, respectively]. Conclusions: 1. Serum concentration of hsIL-6 seems to be better than of CRP marker of periodontal-related inflammation in patients with chronic kidney disease. 2. The main source of periodontal-related inflammation is pulpal necrosis in patients with chronic kidney disease.