Abstract
Odontoblast control of dental pulp inflammation triggered by cariogenic bacteria
Highlights
Inflammation is part of the normal protective immune response of the host to tissue infection
Pulp inflammation accompanies the host’s innate and adaptive immune responses to these bacteria and/or to their components released during bacterial growth that diffuse to the pulp through dentine tubules
Cessation of pulp inflammation generally induces the re-establishment of homeostasis and accurate tissue healing characterized by maintenance of pulp vitality, absence of inflammatory infiltrate and fibrosis, and formation of a barrier of reactionary dentine by surviving original odontoblasts and/or reparative dentine by newly differentiated odontoblast-like cells (Lesot et al, 1994)
Summary
Inflammation is part of the normal protective immune response of the host to tissue infection. Pulp inflammation accompanies the host’s innate and adaptive immune responses to these bacteria and/or to their components released during bacterial growth that diffuse to the pulp through dentine tubules. It generally dampens after pathogen removal by the dental practitioner and neutralization of diffusing components by the pulp immune system, which both decrease the production of pro-inflammatory mediators (Hahn and Liewehr, 2007).
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