Abstract
The article presents the review of the modern approaches and issues in management of the patients with primary hypothyroidism. To date globally multiple nonclinical and clinical studies designed to improve the substitutional therapy and quality of life of patients with primary hypothyroidism are performed. The objective of the review is to analyze the global studies for last 5 years and the modern literature concerning the new possibilities and approaches to the primary hypothyroidism treatment. To achieve this objective the systematic search in PubMed dataset with these key words using: "primary hypothyroidism treatment", "levothyroxine side effects", "primary hypothyroidism outcome", "new approaches to hypothyroidism therapy", "new formulations of levothyroxine", "hypothyroidism in elderly" for the period from 2018 to 2023 was performed. Based on this analysis the conclusions that the investigation of different disease course features and discovering of new treatment options are necessary despite the apparent simplicity of substitutional therapy were made.
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