Abstract

AbstractThis report contains a gene expression summary of the oculomotor nucleus, derived from the Allen Brain Atlas (ABA) in situ hybridization mouse data set. The structure's location and morphological characteristics in the mouse brain are described using the Nissl data found in the Allen Reference Atlas. Using an established algorithm, the expression values of the oculomotor nucleus were compared to the values of the macro/parent-structure, in this case the midbrain, for the purpose of extracting regionally selective gene expression data. The genes with the highest ranking selectivity ratios were manually curated and verified. 50 genes were then selected and compiled for expression characterization. The experimental data for each gene may be accessed via the links provided; additional data in the sagittal plane may also be accessed using the ABA. Correlations between gene expression in the oculomotor nucleus and the rest of the brain, across all genes in the coronal dataset (~4300 genes), were derived computationally. A gene ontology table (derived from DAVID Bioinformatics Resources 2007) is also included, highlighting possible functions of the 50 genes selected for this report.

Highlights

  • This report contains a gene expression summary of the oculomotor nucleus, derived from the Allen Brain Atlas (ABA) in situ hybridization mouse data set

  • The structure's location and morphological characteristics in the mouse brain are described using the Nissl data found in the Allen Reference Atlas

  • The expression values of the oculomotor nucleus were compared to the values of the macro/parentstructure, in this case the midbrain, for the purpose of extracting regionally selective gene expression data

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Summary

Introduction

This report contains a gene expression summary of the oculomotor nucleus, derived from the Allen Brain Atlas (ABA) in situ hybridization mouse data set. The structure's location and morphological characteristics in the mouse brain are described using the Nissl data found in the Allen Reference Atlas. Large motor neurons evenly distributed throughout the structure distinguish the oculomotor nucleus from the surrounding structures This is readily apparent in both the coronal and sagittal Nissl sections, as well as in the Allen Institute ISH data. Nissl-stained sections and Allen Reference Atlas plates reveal the cytoarchitecture and extent of the nucleus and its location in relation to surrounding structures. ISH DATA The images below were selected to highlight various expression patterns of the oculomotor nucleus. Coronal: Another widespread expression pattern showing boundaries of the nucleus

50 SELECT GENES
12 Prss12
Findings
39 Ephx2 40 Manba
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