Abstract
A 61-year-old woman with early-onset parkinsonism developed motor fluctuations with wearing-off and sustained dystonic oculogyric states (DOS) 4 years after starting levodopa therapy (see supplementary video). All of the off-signs were exquisitely responsive to apomorphine. The benefit from each dose of levodopa lasted up to 2 hours; however, peak-dose dyskinesias appeared. …
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