Abstract
Ocular surface regeneration with autologous biomaterials
Highlights
The “Ocular Surface System” includes the specialized epithelium of the cornea and conjunctiva, main and accessory lacrimal glands, meibomian glands, and eyelashes which are in an excellent relationship to maintenance of smooth and wet characters of the anterior window of the eye ball
Various ocular and systemic diseases such as dry eye syndrome, blepharitis associated with meibomian gland dysfunction, ocular allergies, surface scarring from topical treatments, chemical injuries, thermal burns, and immunological disorders (e.g. Stevens Johnson syndrome and mucous membrane pemphigoid) can severely disturb the ocular surface integrity that may result in blurry vision, redness, pain, and even blindness and decrease in the quality of life.[2,3,4]
Urgent surface reconstruction with various biomaterials obtained from different sources, and secondly to proceed the grafted surface integrity with the support of stem cell therapies.[5,6]
Summary
The “Ocular Surface System” includes the specialized epithelium of the cornea and conjunctiva, main and accessory lacrimal glands, meibomian glands, and eyelashes which are in an excellent relationship to maintenance of smooth and wet characters of the anterior window of the eye ball. Since the primary function of the system components is to provide and protect the transparency of the cornea, the corneal epithelium may attributable the chief element in the system.[1] Because of the continuity of the epithelial barrier of the ocular surface with no breaks, a physician should consider to regenerate the whole surface of the eye with a unique and broad-spectrum treatment strategy. Various ocular and systemic diseases such as dry eye syndrome, blepharitis associated with meibomian gland dysfunction, ocular allergies, surface scarring from topical treatments, chemical injuries, thermal burns, and immunological disorders (e.g. Stevens Johnson syndrome and mucous membrane pemphigoid) can severely disturb the ocular surface integrity that may result in blurry vision, redness, pain, and even blindness and decrease in the quality of life.[2,3,4] After definite diagnosis, care and management strategies generally demand highly specialized expertise. Most of the diseases of the ocular surface can be treated with medical strategies, some advanced grade disorders can only be improved with surgical treatments that required some supportive surgical equipments and graft materials
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