Abstract
Weanling rats given a diet containing 300 mg/100 gm para-chlorophenylalanine develop characteristic anterior and posterior lens changes. Approximately 35% continue to complete cataract development and/or a peculiar retractile lens line. Including phenylalanine 1% or 5% to the same diet protects rats against mature cataracts. However, minor lens changes and the refractile line still appear. The absence of any ocular toxicity in monkeys treated with this agent at 300 mg/kg/ day for one year suggests a specific effect only in rats. Mature rats are more resistant to this cataractogenic effect. These lesions do not regress within one year after drug withdrawal.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
