Abstract
Injection of capsaicin or prostaglandin E2 into the vitreous chamber of the rabbit eye resulted in miosis and breakdown of the blood-aqueous barrier, manifested in aqueous flare. Pretreatment with the neuronal blocker tetrodotoxin or the substance P antagonist (D-Pro, D-Trp)-SP greatly reduced the ocular responses to capsaicin and prostaglandin E2. The results suggest a role for neuronal substance P in the ocular response to injury.
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