Abstract
Patients who had been treated with at least one 16-week course of isotretinoin (1 mg/kg) for acne vulgaris were interviewed and examined in order to establish whether there was an increased incidence of eye problems in those who also used contact lenses. Of the total of 157 patients, 11 (7%) wore contact lenses. Significantly more of the patients (63%, 7/11) using contact lenses developed dry eyes, than those not wearing lenses (28%, 41/146). There was no increased risk of infection in the contact lens wearers. Most of the patients (82%, 9/11) who wore contact lenses were able to continue as long as they reduced the duration of use and applied lubricating eye drops. Soft lenses produced fewer problems. We recommend the institution of lubricating eye drops as a matter of course when prescribing isotretinoin to subjects who wear contact lenses, and we emphasize the need for elementary hygiene when handling lenses.
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