Ocular Parameters Quantified by the Swept-Source Optical Coherence Tomography in Celiac Disease / Çölyak Hastalığında Swept-Source Optik Koherens Tomografi ile Ölçülen Oküler Parametreler

Abstract

Objective: To measure anterior and posterior segmental ocular parameters in patients with celiac disease using swept-source optical coherence tomography and compare with those of healthy subjects. Method: Fourteen patients with celiac disease referred from the gastroenterology clinic and 14 control subjects selected from the individuals with minor complaints who admitted the ophthalmology outpatient clinic were included in the study. Mean and segmental retinal nerve fiber layer thickness in four quadrant, average and sectoral ganglion cell inner plexiform layer thickness in six quadrant, foveal and parafoveal vessel density in four quadrant, optic nerve head parameters, including rim area, disc area, horizontal cup-to-disc ratio, vertical cup-to-disc ratio, cup volume, and additionally superficial/deep foveal avascular zone areas, choroidal thickness, and central corneal thickness of patients and controls were quantified using swept-source optical coherence tomography. Results: Among all the measurements, retinal nerve fiber layer in nasal quadrant and subfoveal choroid of patients were significantly thicker than those of controls. Nasal quadrant retinal nerve fiber layer thickness for patients and controls were 91.62±15.27 µm and 79.93±10.43 µm, respectively (P=0.02). Choroidal thickness was 377.69±50.77 µm for patients and 310.93±95.13 µm for controls (P=0.03). Conclusions: Even though celiac disease is primarily a disease of small intestine, this study demonstrated that the disorder can affect the eye as an extra intestinal involvement.