Abstract
BackgroundDiffuse malignant peritoneal mesothelioma and ocular melanoma are both rare tumors. To the best of our knowledge there is only one previous report of three cases in a family with known susceptibility to malignancies associating diffuse malignant peritoneal mesothelioma and ocular melanoma, with no sporadic cases previously reported.Case presentationWe describe the case of a 59-year-old man with a history of diffuse malignant peritoneal mesothelioma, who presented with ocular melanoma 41 months after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy. We also briefly review the literature.ConclusionsDiffuse malignant peritoneal mesothelioma is an uncommon but aggressive disease. As diffuse malignant peritoneal mesothelioma characteristically remains confined to the abdominal cavity, any new extra-abdominal symptom should eventually raise suspicion of another primary tumor. Few cases of diffuse malignant peritoneal mesothelioma associated with other primary tumors have been reported. As ocular melanoma is also infrequent, we suspect a genetic predisposition to these tumors. There is emerging evidence supporting the role of BAP1 mutations in the pathogenesis of these two neoplasias.
Highlights
Diffuse malignant peritoneal mesothelioma and ocular melanoma are both rare tumors
As diffuse malignant peritoneal mesothelioma characteristically remains confined to the abdominal cavity, any new extra-abdominal symptom should eventually raise suspicion of another primary tumor
Few cases of diffuse malignant peritoneal mesothelioma associated with other primary tumors have been reported
Summary
Patients with DMPM who undergo CRS and HIPEC can expect a longer life expectancy in comparison to patients treated by other therapeutic modalities. The association of other primary cancer with DMPM may complicate the management and alter the prognosis for these patients. To the best of our knowledge, this is the first known case report of DMPM and OM occurring in the same individual with no family history. This article is an important element to support the concept of a clinical correlation between DMPM and OM, probably as a BAP1-related cancer syndrome since the probability of the occurrence of both malignancies by chance in the same individual is extremely remote. Genetic testing for BAP1 mutations in this patient and his family is currently in progress and the results will be the subject of another publication. Consent Written informed consent was obtained from the patient for publication of this case report and any accompanying images. Competing interests The authors declare that they have no competing interests
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