Ocular ischemic appearance associated with different carotid artery stenosis degree and its effects on hemodynamics of eye and central retinal artery

Abstract

Objective To observe ocular ischemic appearance (OIA) associated with carotid artery stenosis and its effects on the hemodynamics of central retinal artery (CRA) and ophthalmic artery (OA). Methods A total of 30 normal persons and 60 patients with carotid artery stenosis diagnosed by color Doppler flow imaging (CDFI) and digital subtraction angiography (DSA) were enrolled in this prospective study.Sixty patients were randomly divided into 2 groups: 30 patients with the carotid artery stenosis degree <60% and 30 cases with the carotid artery stenosis degree ≥60%. Thirty normal persons were enrolled in the normal control group. All patients underwent a comprehensive eye examination to determine if OIA exists. The Doppler spectral patterns of CRA and OA were observed by CDFI. The peak systolic velocity (PSV), end diastolic velocity (EDV), blood vessel diameter (BVD) and resistance index (RI) of CRA and OA were measured. Results In the group of the carotid artery stenosis degree≥60%, 24/30 patients (80.0%) had the ophthalmic symptoms and 9/30 patients (30.0%) had ophthalmic signs. In the group of the carotid artery stenosis degree 0.05)and RI(t=0.213, P>0.05)were normal. The PSV, EDV, BVD and RI of CRA in the stenosis 0.05). The PSV(t=4.457, P=0.010)and EDV(t=4.588, P=0.009)of CRA in the stenosis ≥60% group were statistically decreased compared to the stenosis <60% group, but the BVD and RI were the same between these 2 groups. Conclusion Patients with carotid stenosis ≥60% had a higher OIA incidence, reduced PSV, EDV of their CRA, while had no significant changes of OA hemodynamics. Key words: Carotid stenosis/diagnosis; Carotid stenosis/complications; Hemodynamics