Ocular hemodynamics characteristics in patients with diabetic nephropathy

Abstract

Objective To investigate the change of ocular hemodynamics and its relationship with urine albumin excretion ratio in patients with type 2 diabetic nephropathy and to discuss the correlation of ocular microangiopathy with diabetic nephropathy. Methods A total of 168 hospitalized patients with type 2 diabetes were divided into three groups according to urine albumin excretion ratio: normal albumin-uria group (n=63), microalbuminuria group (n=60) and proteinuria group (n=45), and 30 cases of healthy physical examination were chosen as control group. Color Doppler flow imaging was used to quantitate peak systolic velocity (PSV), end diastolic velocity (EDV) and resistance index (RI) of the ophthalmic artery (OA), the posterior ciliary artery (PCA) in the control group and all diabetic patients. Statistic software was used to analyze the hemodynamic parameters. Results Compared with the control group, PSV, EDV of OA and PCA were decreased and RI were increased in diabetic patients (P <0.05). PSV, EDV of OA and PCA were decreased and RI were increased in microalbuminuria group and protein-uria group than no proteinuria group (P <0.05). EDV of OA and PCA were decreased and RI were increased in proteinuria group than microalbuminuria group (P <0.05). UAER were positively correlated with RI of OA and PCA (r=0.521, 0.642, 0.625; P <0.01) and negatively correlated EDV in diabetic patients (r=-0.628,-0.637, P <0.01). Conclusions The ocular hemodynamics is aggravating with the pathological progress of diabetic nephropathy, suggesting the correlation between diabetic choroidopathy and diabetic nephropathy. Key words: Ophthalmic artery; Diabetic nephropathy; Color Doppler flow imaging; Hemodynamics