Abstract
AbstractGanciclovir nanoparticles were prepared using biodegradable polymers to evaluate a possible treatment for cytomegalovirus (CMV) retinitis. Bovine serum albumin (BSA), polyethylcyanoacrylate (PEC), and chitosan were utilized as drug carriers. The three products were evaluated for drug-loading capacity, particle size, and drug release. Spherical nanoparticles ranging between 0.3 and 1.2 μm in diameter were obtained, with those of PEC being the smallest. Loading capacity was in the range of 62.5–66.9%. Drug release studies revealed decreasing release rates in the following order: BSA > PEC ≥ chitosan. PEC nanoparticles containing ganciclovir (measured spectrophotometrically) and radioactive acyclovir (measured by liquid scintillation) showed essentially the same release patterns. The PEC nanoparticles containing [3H]acyclovir and ganciclovir together were selected for in vivo drug level studies. Following an intravitreal injection in rabbit eyes, drug levels in different eye tissues were used to comp...
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