Ocular complications of pediatric bone marrow transplantation

Abstract

Objective To investigate the ocular complications in pediatric bone marrow transplantation (BMT) patients. Design Cross-sectional study. Participants A total of 29 pediatric BMT patients were studied. Testing Comprehensive ophthalmic check-up, including best-corrected visual acuity, intraocular pressure (IOP), Schirmer’s test, tear breakup time, and slit-lamp and fundus examinations, was performed. Main outcome measures Tear film instability and its related complications, IOP, cataract, and fundus lesions were measured. Results The mean age of patients was 9.1 years (range, 1.5–15 years). The mean post-BMT duration was 20.2 months (range, 3–54 months). Fifteen patients (51.7%) had tear abnormalities. Subconjunctival fibrosis was detected in two patients (6.9%). Dry and scaly skin of the eyelids was seen in one patient (3.4%). Lens opacities were found in 2 (33.3%) of 6 irradiated patients and 2 (8.7%) of 23 nonirradiated patients. Two patients (6.9%) had fundus changes, one with unilateral epiretinal membrane and the other with bilateral multiple discrete chorioretinal hypopigmented lesions in the middle to peripheral part of the retina. The overall complication rates for the anterior and posterior segments were 75.8% and 6.9%, respectively. Conclusion Ocular manifestations of BMT in children are not uncommon. The most common anterior segment problem is tear dysfunction. Posterior segment complications are less common but do exist. High rate of cataract formation is reported, and this probably is the most important long-term “amblyogenic” problem in these immature eyes. Awareness and management of these problems with routine eye examination and early intervention are recommended.