Abstract
BackgroundThis study aimed to identify the features of ocular biometry in patients with EYS-related retinitis pigmentosa using IOLMaster 700.MethodsWe retrospectively reviewed the medical records of patients with retinitis pigmentosa. Patients with records of the following were included: (1) ocular biometry measurements using the IOLMaster 700 and (2) genetic diagnostic tests. Axial length, keratometry, anterior chamber depth, aqueous depth, lens thickness, central corneal thickness (CCT), and corneal diameter (white to white) measurements were extracted. Based on keratometry measurements, (1) standard keratometric astigmatism, (2) posterior corneal astigmatism, and (3) total corneal astigmatism were obtained. Demographics and biometric parameters were compared between patients with EYS-related retinitis pigmentosa and other patients with retinitis pigmentosa.ResultsA total of 86 eyes of 44 patients (23 females and 21 males; mean age: 47.7 years) with retinitis pigmentosa were included. Of these, 18 were identified as having EYS variants. CCT was significantly thinner (P < 0.001) and the posterior corneal curvature at the steepest meridian was significantly smaller (P = 0.024) in patients with EYS-related retinitis pigmentosa than in other patients with retinitis pigmentosa. The magnitudes of all corneal astigmatism measurements was higher in patients with EYS-related RP, although these differences were not statistically significant.ConclusionPatients with EYS-related retinitis pigmentosa had unique features in ocular biometry, such as thinner central corneal thickness and smaller posterior corneal curvature radius at the steepest meridian compared with other patients with retinitis pigmentosa. The findings suggest that patients with retinitis pigmentosa have different ocular dimension features among the different causative genes.
Highlights
This study aimed to identify the features of ocular biometry in patients with EYS-related retinitis pigmentosa using IOLMaster 700
Sakai et al BMC Ophthalmology (2022) 22:51 a few reports that describe the alterations in the anterior segment [2, 3], detailed ocular biometry in patients with Retinitis pigmentosa (RP) is not yet fully understood
In addition to standard keratometry in which the corneal curvature radius at the flattest meridian (R1) and steepest meridian (R2) is Materials and methods This retrospective study included patients diagnosed with RP who were followed up at the Kobe City Eye Hospital between June 2020 and December 2020
Summary
This study aimed to identify the features of ocular biometry in patients with EYS-related retinitis pigmentosa using IOLMaster 700. The IOLMaster 700 (Carl Zeiss AG, Oberkochen, Germany) is the first swept-source optical coherence tomography (OCT)-based biometry device that provides anatomical details of the complete longitudinal section of the eye; all axial measurements including axial length, central corneal thickness (CCT), anterior chamber depth (ACD), and lens thickness can be obtained. Some causative genes have specific pathological conditions complicated with the retinal dystrophy, for example, high myopia in RPGR variants [7] or angle-closure glaucoma in CRB1 and MFRP variants [8,9,10] These reports have suggested that patients with RP may have different alterations in ocular dimensions among different causative genes. This pilot study aimed to investigate the hypothesis that different causative genes are associated with different ocular biometry findings, by identifying the features of IOLMaster 700-based total ocular biometry in patients with EYS-related RP
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