Abstract
BackgroundThe purpose of this study is to evaluate the spectrum of scleritis from database of Ocular Autoimmune Systemic Inflammatory Infectious Study (OASIS) at a tertiary eye referral eye institute in Singapore. Clinical records of 120 patients with scleritis from a database of 2200 patients from Ocular Autoimmune Systemic Inflammatory Infectious Study (OASIS) were reviewed.Results56.6% were females, with a mean age of 48.6 ± 15.9 years. 75 (62.5%) had diffuse anterior scleritis, 25 (20.8%) had nodular anterior scleritis, 7 (5.8%) had necrotizing anterior scleritis and 13 (10.8%) had posterior scleritis. Ocular complications were observed in 53.3% of patients, including anterior uveitis (42.5%), raised intraocular pressure (12.5%), and corneal involvement (11.7%). Autoimmune causes were associated with 31 (25.8%) of patients, and 10 (8.3%) patients had an associated infective etiology, much higher than Caucasian studies. 53.3% of patients were treated with oral corticosteroids while 26.7% required immunosuppressives.ConclusionsInfective etiology needs to be considered in patients of scleritis from Asian origin. In our study and in OASIS database, scleritis was associated with systemic autoimmune disease and ocular complications.
Highlights
The purpose of this study is to evaluate the spectrum of scleritis from database of Ocular Autoimmune Systemic Inflammatory Infectious Study (OASIS) at a tertiary eye referral eye institute in Singapore
We aim to analyze our clinical experience with this disorder, in particular, the associated systemic diseases, complications, treatments methods, and outcomes of patients with scleritis presenting to a tertiary institution in Singapore from a very large database of ocular inflammatory disease—Ocular Autoimmune Systemic Inflammatory Infectious Study (OASIS) database
One hundred and twenty patients (5.45%) with scleritis were identified during this 11-year period, out of a total of 2200 patients that presented to our Uveitis and Ocular Inflammation service
Summary
The purpose of this study is to evaluate the spectrum of scleritis from database of Ocular Autoimmune Systemic Inflammatory Infectious Study (OASIS) at a tertiary eye referral eye institute in Singapore. Clinical records of 120 patients with scleritis from a database of 2200 patients from Ocular Autoimmune Systemic Inflammatory Infectious Study (OASIS) were reviewed. Scleritis is an uncommon potentially sight threatening ocular inflammatory disease [1, 2]. It is typically a severe painful inflammatory process characterized by inflammation of the sclera associated with engorgement of the conjunctival, superficial, and deep episcleral vessels. Necrotizing scleritis, in particular, has been more frequently associated with ocular complications [3, 4] Ocular complications include scleral and corneal thinning, perforation, keratitis, anterior uveitis, glaucoma, cataract, and exudative retinal detachment [1, 3].
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