Abstract
lymphoma and therefore helpful in differential diagnosis. In this study, we describe 5 cases of extramedullary plasmacytoma arising in immunocompetent individuals that were diffusely positive for Epstein-Barr virus encoded small RNA by in situ hybridization. These tumors were characterized by a diffuse proliferation of mature appearing plasma cells intermixed with a brisk reactive, CD8+, TIA1+ T-cell infiltrate. Long-term follow-up was available for all patients (median 44.1 months). All patients were alive and free of disease at last follow up. It is essential to appropriately identify these neoplasms, which we have designated as EBV+ plasmacytoma in immunocompetent patients (EPIC), and to distinguish these tumors from plasmablastic lymphoma as the latter diagnosis is associated with a poor prognosis and patients require much more aggressive therapy.
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
