ÇOCUKLUK ÇAĞI HEMANJİOMLARININ TEDAVİSİNDE TOPİKAL VE ORAL BETA-BLOKERLERİN ETKİNLİĞİNİN KARŞILAŞTIRILMASI

Abstract

Purpose: Hemangiomas are the most common vascular tumors of childhood, and the treatment options have undergone profound changes in recent years. We aimed to compare the effectiveness and safety of non-pharmacological treatment, topical beta blocker treatment, and and oral beta blocker treatment in the treatment of superficial and deep hemangiomas in the pediatric age group. 
 Material and Methods: We retrospectively reviewed the medical records of pediatric patients with hemangioma. 
 Results: Fifty-three patients (F/M=40/13) were enrolled in this study. Superficial hemangiomas were detected in 14 (26.4%) patients, and deep hemangiomas in 39 (73.6%). Seventeen patients were followed without medication, 19 patients were treated with a topical beta blocker , and 17 patients were treated with an oral beta blocker. Twelve patients with a superficial hemangioma were followed without medication while two patients received topical timolol treatment.
 A comparison of the lesion progress in the patients with superficial hemangiomas in non-pharmacological treatment and topical treatment groups, the mean scores of success in terms of mean fading and reduction in lesion depth were significantly higher at 1st month (7.0 vs 1.66; p=0.049; 6.0 vs 1.5; p=0.045). 
 Among patients with deep hemangiomas, a comparison of mean fading scores showed no difference between the oral and topical treatment groups at both 1st and 4th month (p=0.551, p=0.551). 
 Conclusion: We believe that topical treatment can replace oral beta blockers in the future, and will likely be more preferred by clinicians and families because of their fewer side effects.