Abstract
Objective: To investigate the effects of carbamazepine therapy on thyroid function tests in children Methods: The carbamazepine group consisted of 58 children under observation for epilepsy, and the control group of 54 healthy children. Age of onset, length of drug use, drug dosage and laboratory parameters including free triiodothyronine (FT3), free thyroxin (FT4) and thyrotropin (TSH) were recorded. These data were then compared against those from the control group. Results: In the carbamazepine group, FT3 was 3.86 p 0.43 pg/mL, FT4 was 1.15 p 0.18 mg/dL and TSH: 2.58 p 1.33 ml U/L. In the control group, FT3 was 4.13 p 0.59 pg/mL, FT4 1.34 p 0.13 mg/dL and TSH was 2.06 p 0.89 ml U/L. No statistically significant difference between rates of subclinical hypothyroidism was determined between the two groups (p=0.196). Conclusion: Although, carbamazepine reduces thyroid hormone concentrations, rarely causes hypothyroidism.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
