Abstract
We read with interest the report by McLaughlin et al 1 McLaughlin SA Crandall CS McKinney PE Octreotide: an antidote for sulfonylurea-induced hypoglycemia. Ann Emerg Med. 2000; 36: 133-138 Abstract Full Text Full Text PDF PubMed Scopus (89) Google Scholar (article #108183) on the use of octreotide for the treatment for sulfonylurea-induced hypoglycemia. In patients with alleged sulfonylurea overdose, the decrease in hypoglycemic episodes after administration of octreotide is striking. However, we have a few questions for the authors. Octreotide: An antidote for sulfonylurea-induced hypoglycemiaAnnals of Emergency MedicineVol. 36Issue 2PreviewStudy Objectives: Sulfonylurea agents are widely used as therapy for hyperglycemia in type 2 diabetes mellitus. In overdose, these agents can produce sustained and profound hypoglycemia that is refractory to treatment with dextrose alone. Our objective was to determine whether treatment with octreotide decreases glucose requirements and the number of hypoglycemic episodes in patients with sulfonylurea-induced hypoglycemia. Methods: We retrospectively reviewed the charts of patients treated with octreotide for sulfonylurea-induced hypoglycemia from 1995 through 1998. Full-Text PDF
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