Abstract
SummaryOCT has become already a standard diagnostic tool in ophthalmology. Despite its continuous improvement in performance, its tissue specificity is still limited, as the contrast mechanism relies on local backscattering changes only. Functional extensions of OCT, in particular Doppler OCT and angiography partially mitigate this limitation. Doppler OCT provides quantitative blood flow in a depth‐localized manner. Abnormal changes in total retinal blood flow have been related to major retinal diseases and their assessment might therefore be an early biomarker of disease onset. Recent developments overcome the necessity to determine the Doppler angle for flow quantification. Fast OCT sequences resolve the pulsatile blood flow in circumpapillary vessel cross sections, that allow to determine the total retinal perfusion in reliable manner. OCT Angiography (OCTA) has gained much attention, due to its easy operation, and impressive vascular detail. It operates in a fully non‐invasive manner, directly on OCT data, and as such as naturally co‐registered. Several examples are given to highlight recent developments to improve speed, field‐of‐view and penetration depth.
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