Abstract
SummaryOptical coherence tomography (OCT) and In vivo confocal microscopy (IVCM) are two very useful imaging modalities in examination of the cornea. OCT provides non‐contact, cross sectional images with a wide angle of view, under high magnification, simulating histology but in fact are dependent on the reflectivity of tissues. Imaging through scars is poor. Clinically is it very useful in examining interfaces created by refractive surgery and lamellar corneal surgery.IVCM provides en‐face images with a restricted field of view but with a resolution range of 1.5–4 μm allowing examination at a cellular level. The different layers of the epithelium, sub‐basal plexus, Bowman's zone, stroma with keratocytes and nerves, the Descemet's membrane and endothelial cells can be clearly visualised in health and disease. Besides providing detailed morphology of the above structures it also enable visualisation of invading organisms such as acanthamoeba and fungi.Software associated with both OCT and IVCM allow measurement of dimensions of objects/area (s) of interest. OCT is more accurate in measurement of depth while IVCM enables quantification of cell size, shape and numbers. Interpretation skills require experience for both.
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