Oct-1 functions as a sensor for metabolic and stress signals

Abstract

Oct-1 is a member of the POU domain transcription factor family. The protein in this family typically contains a bipartite DNA binding domain, in which two sub-domains, covalently connected by a flexible linker, normally recognize DNA through major groove interaction on the opposite sides of the helix. The classical recognition sequence is known as the octamer motif “ATGCWAAT”, where W can be either “A” or “T”. This ubiquitously expressed transcription factor exerts multiple biological functions via up or downregulating the expression of a large profile of target genes in different cell lineages, including those in pancreatic islets. Apparently, it is essential for embryonic development as Oct-1-deficient embryos die during gestation. Recent studies from our group and others revealed that Oct-1 serves as a sensor for both metabolic as well as stress/survival signals.