Abstract
BackgroundPrevious studies described cases of Ocriplasmin injections in patients with vitreo-macular traction and reduced central visual acuity. We describe the first case of a patient with 20/20 visual acuity and vitreo-macular traction treated with Ocriplasmin, and, for the first time in literature, we evaluated the functional changes of the macula in response to pharmacological treatment through multifocal-electroretinogram.Case presentationWe report the case of a female Caucasian patient aged 67 years with vitreo-macular traction in the right eye, treated with Ocriplasmin, at the Eye Clinic of the Second University of Naples. Visual acuity was 20/20 before treatment, associated with metamorphopsia. Two weeks after injection, optical coherence tomography showed the release of vitreo-macular traction and multifocal electroretinogram responses showed a significant increase of retinal density responses in all six rings (p < 0.03). Visual acuity remained constant with resolution of symptoms and the appearance of vitreous floaters.ConclusionIntravitreal injection of Ocriplasmin resulted to be a safe and effective treatment in the case here reported. Our data show that the anatomical recovery with release of vitreo-macular traction was associated with a full functional recovery. In fact, the electrical retinal density response of the macular area improved two weeks after Ocriplasmin injection. Further studies with broader inclusion criteria for Ocriplasmin treatment (e.g. also with visual acuity higher than 20/25) on a larger study sample are needed to confirm our results.
Highlights
Previous studies described cases of Ocriplasmin injections in patients with vitreo-macular traction and reduced central visual acuity
Our data show that the anatomical recovery with release of vitreo-macular traction was associated with a full functional recovery
We describe the case of a 67-year-old woman with VMT in the right eye, visual acuity of 20/20 and metamorphopsia, treated with intravitreal Ocriplasmin
Summary
Intravitreal injection of Ocriplasmin was a safe and effective treatment in our case, characterized by a preserved visual acuity. Our data show that the anatomical recovery with release of VMT is associated with a full functional recovery, without visual acuity loss. The electrical retinal density response of the macular area improved two weeks after Ocriplasmin injection. Appropriate attention to details is important in patient selection as such selection of suitable candidates could determine good outcomes following treatment with Ocriplasmin. Since the present study reports only one case, further studies on an adequate sample are needed in order to approve broader selection criteria including subjects with higher visual acuity. All authors read and approved the final manuscript
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