Abstract
Arenavirus RNA was isolated from Mexican deer mice (Peromyscus mexicanus) captured near the site of a 1967 epidemic of hemorrhagic fever in southern Mexico. Analyses of nucleotide and amino acid sequence data indicated that the deer mice were infected with a novel Tacaribe serocomplex virus (proposed name Ocozocoautla de Espinosa virus), which is phylogenetically closely related to Tacaribe serocomplex viruses that cause hemorrhagic fever in humans in South America.
Highlights
Arenavirus RNA was isolated from Mexican deer mice (Peromyscus mexicanus) captured near the site of a 1967 epidemic of hemorrhagic fever in southern Mexico
Bayesian analyses of complete glycoprotein precursor (GPC) gene sequences (Figure 2, panel A) and complete N protein gene sequences (Figure 2, panel B) separated the Tacaribe serocomplex viruses into 4 groups (A, B, C, D)
Arenavirus AV B1030026 was included in group B with Amaparí virus (AMAV), Cupixi virus (CPXV), Tacaribe virus (TCRV), and the 5 viruses from South America known to cause hemorrhagic fever in humans
Summary
Arenavirus RNA was isolated from Mexican deer mice (Peromyscus mexicanus) captured near the site of a 1967 epidemic of hemorrhagic fever in southern Mexico. Five members of the Tacaribe serocomplex (CHPV, GTOV, JUNV, MACV, and SABV) cause hemorrhagic fever in humans [6,7]. Diseases caused by these viruses are zoonoses. A recently published study reported antibody against a Tacaribe serocomplex virus in 3 (25.0%) of 12 Mexican deer mice (Peromyscus mexicanus) and 0 of 29 other cricetid rodents captured in the municipality of Ocozocoautla de Espinosa, State of Chiapas, Mexico [14]. Analyses of serologic data suggested that the 3 antibody-positive deer mice were infected with an arenavirus that is antigenically more closely related to the South American hemorrhagic fever arenaviruses than to other North American Tacaribe serocomplex viruses. The objective of this study was to determine the identity of the Tacaribe serocomplex virus associated with P. mexicanus deer mice in western Chiapas
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