Ocena stężeń adiponektyny i leptyny w surowicy u pacjentów z chorobą niedokrwienną serca — związek z frakcją wyrzutową, wskaźnikiem uwapnienia tętnic i angiogramem tętnic wieńcowych

Abstract

Introduction. Adiponectin is an adipose tissue-derived adipocytokine protein, while leptin is the protein that maintains the body weight in humans via its effect on the hypothalamus. These hormones interact at different levels of cardio-metabolic risk factors. This study aimed to assess the serum levels of adiponectin and leptin in patients with ischaemic heart disease and subjected to coronary calcium scoring (CCS) and coronary angiography. Material and methods. We included 59 patients with ischaemic heart disease and 20 healthy subjects served as a control in this study. The patients were assessed by electrocardiograph, echocardiograph, coronary angiogram and coronary computerised tomography (CCT) for the assessment of CCS. Serum levels of adiponectin and leptin were determined by using enzyme-linked immunosorbent assay (ELISA) technique. Results. Coronary computed tomography (CT) investigation explored, that 30.5% of patients had positive calcium score and 67.8% of patients did not show evidence of coronary changes by CT angiograph. The patients had significantly high leptin and low adiponectin levels compared with healthy subjects. Serum leptin levels were significantly low in patients with positive CCS and angiogram, compared with those who had no abnormal CCT. Significant positive correlation between ejection fraction and serum leptin (r = 0.285, p < 0.05) and non-significant correlation with serum adiponectin were observed. Conclusions. Serum leptin and adiponectin levels are useful determinants in patients with ischaemic heart disease, as high serum leptin levels are associated with negative coronary CT and positively correlated with left ventricular ejection fraction.