Ocena stanu mikrokrążenia na podstawie stymulacji oscylacji miogennych przez przejściowe niedokrwienie

Abstract

Microcirculation oscillations, known as flowmotion, are a well-recognized feature of blood flow through blood vessels. There is evidence that impaired microvascular flow can be a symptom of a variety of diseases, including diabetes, cancer and cardiovascular disease, as well as neurodegenerative and autoimmune diseases. The innovative Flow Mediated Skin Fluorescence (FMSF) technique enables direct and precise monitoring of microcirculation oscillations, giving a qualitative and quantitative picture of the microcirculatory status of the organism. The HS (Hypoxia Sensitivity) parameter, determined by the FMSF technique, allows to quantify the degree of sensitivity of the organism to hypoxia by measuring stimulation of myogenic oscillations by transient hypoxia. It is assumed that an organism’s sensitivity to hypoxia may be regulated by genetic factors, but many studies indicate a significant role of hypoxia-inducible factor (HIF) in such response. The HS parameter seems to reflect a level of stabilized HIF-1α during the transient hypoxia caused by temporary occlusion of the brachial artery. The HS parameter can be used to predict development of the diseases accompanied by hypoxia. Based on the relationship between the innate immune response and hypoxia it can also be used to predict the severity of the disease such as coronavirus disease 2019 (COVID-19) infection. A good response to hypoxia (high values of HS parameter) can predispose the individuals to endurance training (long-distance running, climbing etc. ). Amateurs’ physical activity should also be undertaken based on the microcirculatory response to hypoxia. The FMSF technique allows to detect microcirculation disorders at an early stage in order to identify patients for preventive or therapeutic intervention, or for further more accurate and complex diagnostic tests.